| 摘要 |
Pharmaceutical compositions comprise 1 to 40% by weight of sialic acid with 99 to 60% by weight of animal mucin, and may include a culture of one or more non-pathogenic, aerobic or anaerobic living bacteria. The bacteria used are those which are normal hosts of the human intestine, and preferably are of strains resistant to antibiotics; they are suitably in the form of lyophilised cultures. Suitable species include Escherichia coli; Bacillus bifidus; Lactobacillus lactis; L. bulgaris; Clostridium sporogenes; L. bulgaricus and Streptococcus faecalis. The cultures may be protected in the compositions by the addition of buffering agents and/or amino acids, and are administered orally in the form of capsules.ALSO:Compositions for treating disorders of the muscous membranes comprise 1 to 40% by weight of N-acetyl neuraminic acid (sialic acid) with 99 to 60% of mucoprotein and/or mucopolysaccharide, optionally to which are added one or more other medicaments. The mucoprotein-mucopolysaccharide constituent is provided by a mucin of animal origin, which when it contains per se sufficient sialic acid, can provide the sole essential ingredient of the composition. Such sialic acid-rich mucins include those derived from the intestines, sub-maxillary, sub-lingual or genital glands of sheep, pigs or cattle. Alternatively a mucin with little or no sialic acid, e.g. gastric mucin, may be suitably fortified by addition of sufficient of the acid or of an acid-rich mucin. The compositions are for oral, rectal or topical application, and may take the form of solutions, ointments, jellies, powders, dragees, tablets, gelatine coated pills or suppositories. Other active ingredients include absorbent gastric agents such as silicates, kaolin, and aluminium and bismuth salts; antirheumatics, e.g. butazolidine (Registered Trade mark); antispasmodics and anticholinergics such as atropine or belladonna; local anaesthetics such as lignocaine; steroids such as cortisone; sedatives and tranquillisers such as pheno barbitone, reserpine and meprobamate; antihistoamines, e.g. phenergan (Registered Trade Mark); and aperients, e.g. mucilages, and antiseptics, e.g. collargol (a colloidal silver preparation). The preferred compositions contain cultures of non-pathogenic antibiotic resistant living bacteria, (see Division C6) of which many are listed, and may also contain amino acids, specifically glutamic acid, aspartic acid, arginine, leucine, glycine, alanine, valine, asparagine, lysine, leucylglycine, histidine, or other C2 to C10 amino acids. The compositions may include buffering agents such as alkali metal phosphates, tartrates, citrates, or aspartates. Examples are given for preparing oral compositions in capsule form and a suppository, and also for a method of preparing mucin from animal glands.
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