Screening method for identifying an agent that modulates PIPKIgamma trafficking of E-cadherin

摘要

The present disclosure teaches that PIPKIgamma binds cadherins and adaptor protein mu-subunits and mediates trafficking of cadherins to and from the plasma membrane. Thus, the present invention relates to a method for identifying agents which modulate the trafficking or binding activities of a PIPKIgamma. A method for diagnosing and prognosing a cancer derived from epithelial cells by detecting the amount and subcellular location of PIPKIgamma is also provided as is a method for preventing or treating a disease or condition involving PIPKgamma activity or cadherin localization.