A method of treating a neurodegenerative disease in a subject in need thereof comprises: (a) administering the subject an ornithine decarboxylase inhibitor such as alpha-difluoromethylornithine or a pharmaceutically acceptable salt or prodrug thereof in an amount effective to treat the disease; and concurrently (b) administering the subject a polyamine or a pharmaceutically acceptable salt or prodrug thereof in an amount effective to reduce damage to the gastroinestinal tract of the subject by the ornithine decarboxylase inhibitor.
申请公布号
WO2006133231(A3)
申请公布日期
2007.07.12
申请号
WO2006US21998
申请日期
2006.06.07
申请人
DUKE UNIVERSITY;COLTON, CAROL, A.;VITEK, MICHAEL, P.;STRITTMATTER, WARREN, J.;XU, QING;BURKE, JAMES R.
发明人
COLTON, CAROL, A.;VITEK, MICHAEL, P.;STRITTMATTER, WARREN, J.;XU, QING;BURKE, JAMES R.