INTRANASAL DELIVERY SYSTEM

摘要

This invention relates to apparatus and methods of delivering various compositions including medicaments to a variety of targets. The invention includes a dose administrator ( 1 ) which may be used for intranasal delivery of compositions or medicaments, such as live virus vaccines, to both humans and animals. An axial collapse prevention element ( 2 ) to prevent excessive axial deflection of the dose administrator ( 1 ) or a dose-location coordinate indicator ( 3 ) to facilitate the delivery of a dose to the desired target location may be coupled to the dose administrator ( 1 ). An intranasal probe ( 4 ) having a force dissemination contact surface ( 7 ) may be responsive to a first end of the dose administrator ( 1 ). The dose may be delivered from a conformable dose sequestration element ( 10 ) through an aperture which penetrates the dose delivery aperture element ( 5 ) and the dose may be caused to stream by coupling a stream delivery element ( 6 ) to the dose delivery aperture element ( 5 ). The force application element ( 12 ) which acts upon the dose may be separated from the dose by a fluid dose propellent ( 13 ). While the invention may be used for numerous applications, it specifically addresses the difficulties of delivering cold-adapted live equine influenza viruses intranasally to equids.