MULTIDOMAIN RNA MOLECULES COMPRISING AT LEAST ONE APTAMER FOR DELIVERING DOUBLE STRANDED RNA TO PEST ORGANISMS

摘要

The present invention relates to methods and constructs for delivering double stranded RNA (dsRNA) to pest organisms. More specific, the invention relates to a multidomain RNA molecule consisting of a nucleotide sequence comprising (i) at least one aptamer and (ii) at least one nucleotide sequence of interest forming double-stranded RNA, said double-stranded RNA comprising annealed complementary strands, one of which comprises a nucleotide sequence which is complementary to at least part a pest target nucleotide sequence. The invention further relates to nucleic acids encoding the multidomain RNA molecules and to various uses of the multidomain RNA molecules in agriculture.