CREATING AN AEROSOLIZED FORMULATION OF INSULIN

摘要

Devices, packaging and methodology for efficiently and repeatably creating aerosolized bursts of an insulin containing formulation are disclosed. Devic es are hand-held, self-contained units which are automatically actuated at the same release point in a patient's inspiratory flow cycle. The release point is automatically determined either mechanically or, more preferably calculated by a microprocessor which receives data from a sensor making it possible to determine inspiratory flow rate and inspiratory volume. Actuation of the device forces insulin formulation through a porous membrane (3) of the container (1) which membrane has pores having a diameter in the range of abo ut 0.25 to 3.0 microns, preferably 0.25 to 1.5 microns.