| 摘要 |
FIELD: synthesis of biologically active compounds. ^ SUBSTANCE: invention provides novel compounds of general formula I: (I), in which R1, R2, independently from each other, represent H, OH, OR5, or Hal; R3, R3', independently from each other, represent H or Hal; R4 represents CN or group ; R5 is A or cycloalkyl having 3 to 6 carbon atoms optionally substituted by 1-5 F and/or Cl atoms, or -(CH2)-Ar group; A represents C1-C10-alkyl optionally substituted by 1-5 F and/or Cl atoms; Ar is phenyl; n = 0, 1 or 2; Hal is F, Cl, Be, or I; and pharmaceutically acceptable derivatives thereof, solvates, and stereoisomers, including their mixtures in any proportions. Invention also relates to a method of preparing compounds I, pharmaceutical agent manifesting inhibitory activity relative to phosphodiesterase IV, application areas, and intermediate compounds of formula I-I. ^ EFFECT: expanded synthetic possibilities in novel biologically active compounds areas. ^ 14 cl, 4 tbl, 19 ex
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