INJECTABLE HYDROGELS BASED ON HYALUONIC ACID FOR TISSUE REGENERATION

摘要

Provided are an acrylated hyaluronic acid derivative or its salt, its preparation method, a crosslinked hydrogel using the derivative or salt which can be injected in vivo and regenerates tissue with minimum damage, and a composition for regenerating tissue or preventing re-adsorption containing the hydrogel. The acrylated hyaluronic acid derivative is represented by the formula(1), wherein R is -NH-CO-(CH2)n-CO-NH-; and n is 4-8. The acrylated hyaluronic acid derivative is prepared by reacting hyaluronic acid and a diamine represented by H2N-R-NH2 in the presence of a polymerizing agent; and reacting the obtained one with an acrylating agent. Preferably the acrylating agent is N-acryloxysuccinimide. The hydrogel is prepared by crosslinking the acrylated hyaluronic acid derivative of the formula(1) or its salt with a crosslinking agent having a thiol group.