| 摘要 |
FIELD: organic synthesis. ^ SUBSTANCE: invention provides a method of preparing 3-indolylphenylmethyl-2-substituted cyclic alpha-ketones having general formula: , in which R represents 1 or 2 carbon atoms with annelated benzene ring or substituted methylidene group, in particular 2-methylpropylidene or 2-phenylmethylidene group, and consists in that alpha-phenyl-norgramine is brought into reaction with cyclic ketone of general formula: , wherein R is defined above, in boiling isopropyl alcohol in presence of sodium acetate, pyridine, triethylamine, alkali, or chiral amine as base. ^ EFFECT: expanded synthetic possibilities in a series of indolyl derivatives. ^ 3 tbl, 6 ex |
