Uses of THANK, a TNF homologue that activates apoptosis

摘要

The present invention is directed to the applications of a novel cytokine, named THANK, for TNF homologue that activates apoptosis, NF-kappaB and c-jun N-terminal kinase. Such applications include using THANK inhibitors to inhibit the activation of NF-kappaB and to treat a pathological condition caused by the activation of NF-kappaB. Also provided is a method of inhibiting growth of a wide variety of tumor cells by administering THANK protein.