FOMITOPSIS PINICOLA EXTRACT HAVING DIABETES COMPLICATION PREVENTIVE EFFECT AND THE USE THEREOF

摘要

A composition comprising an extract of Fomitopsis pinicola fruiting body or Fomitopsis pinicola cultural mycelium is provided to inhibit the activity of aldose reductase and decrease the concentration of neutral lipid, total cholesterol, and LDL cholesterol, thereby being effective for treating and preventing diseases caused by the increase of the aldose reductase activity such as cataract and nephropathy. The composition for treating and preventing diabetic complication induced by the aldose reductase activity increase comprises an extract of Fomitopsis pinicola fruiting body or an extract of Fomitopsis pinicola cultural mycelium. The extract of Fomitopsis pinicola fruiting body is a hot-water extract or an alkali-extract. The extract of Fomitopsis pinicola cultural mycelium is prepared by the method comprising the steps of: (a) subculturing and seed-culturing cultural mycelium seeds of the Fomitopsis pinicola; (b) inoculating the seeds into a sterilized and cooled potato culture medium and then culturing it; (c) neutralizing the cultured solution obtained from the step(b) and then precipitating it into ethanol; and (d) dialyzing the precipitate.