| 摘要 |
PROBLEM TO BE SOLVED: To provide a medicinal composition containing a new pyrrolidine derivative having excellent CBI receptor antagonism as an active ingredient. SOLUTION: The medicinal composition contains a compound represented by general formula (I) [wherein, R<SP>1</SP>and R<SP>2</SP>are each independently a (substituted) aryl (or heteroaryl) group; one of R<SP>3</SP>and R<SP>4</SP>is a hydrogen atom, and the other is a hydrogen atom, a hydroxy group, an alkyloxy group or the like; R<SP>5</SP>is a hydrogen atom or an alkyl group; Y is a single bond, an oxygen atom or a group represented by formula: -N(R<SP>7</SP>)-; R<SP>6</SP>is a (substituted) linear or branched hydrocarbon group or a (substituted) cyclic group; and R<SP>7</SP>is an alkyl group or an alkyloxycarbonylalkyl group] or a pharmacologically acceptable salt thereof as an active ingredient. COPYRIGHT: (C)2007,JPO&INPIT
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