摘要 |
<p>A process for preparation of (4-oxo-2-thioxo-1,3-thiazolidin-3-yl) acetic acid comprising: (a) reaction of compound of formula (VIII) wherein Y is Cl, Br, I, OTs, OMs and R is C<SUB>1-8</SUB> alkyl, benzyl, cycloalkyl, phenyl, substituted phenyl and their like; with a compound of formula (VIIIA) wherein M is K, Na or Li, preferably K; R<SUB>1 </SUB>is C<SUB>1-4</SUB> alkyl, benzyl, C<SUB>1</SUB>-C<SUB>8 </SUB>cycloalkyl, phenyl and their like, in aqueous medium to give a compound of formula (IX) (b) cyclizing a compound of formula (IX) using a base to give a compound of formula (X) in a solvent. (c) hydrolyzing (X) using aqueous mineral acid.</p> |
申请人 |
KHAMAR, BAKULESH, MAFATLAL;MODI, INDRAVADAN, AMBALAL;VENKATRAMAN, JAYARAMAN;RAVI, PONNAIAH;DESAI, SANJAY, JAGADISH;SINGH, RAMESH, CHANDRA;SONDAGAR, KEVAL, RAMESHKUMAR |
发明人 |
KHAMAR, BAKULESH, MAFATLAL;MODI, INDRAVADAN, AMBALAL;VENKATRAMAN, JAYARAMAN;RAVI, PONNAIAH;DESAI, SANJAY, JAGADISH;SINGH, RAMESH, CHANDRA;SONDAGAR, KEVAL, RAMESHKUMAR |