发明名称 COMBINATION OF TEMOZOLOMIDE AND alpha-IFN FOR TREATMENT OF ADVANCED CANCER
摘要 PROBLEM TO BE SOLVED: To provide a method for the treatment of advanced cancer in which the response ratio is increased and/or the side action is decreased. SOLUTION: The method for the treatment of advanced cancer in a patient in need of such treatment includes a step to administer temozolomide andα-interferon in an amount sufficient to achieve a clinical response. In one embodiment, the temozolomide is administered for 2-10 days in an amount of 50-400 mg per 1 m<SP>2</SP>of the surface area of the patient per day, and theα-interferon is administered 1-7 times per one week by intravenous or subcutaneous administration at a rate of 1,000,000-25,000,000 IU per 1 m<SP>2</SP>of the surface area of the patient. COPYRIGHT: (C)2007,JPO&INPIT
申请公布号 JP2007169300(A) 申请公布日期 2007.07.05
申请号 JP20070080381 申请日期 2007.03.26
申请人 SCHERING PLOUGH CORP 发明人 DUGAN MARGARET H
分类号 A61K38/21;A61K31/00;A61K31/415;A61K31/4164;A61K31/4188;A61K45/06;A61P35/00 主分类号 A61K38/21
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