发明名称 |
MATERIALS AND METHODS RELATED TO DICKKOPFS (DKK) AND NEUROGENESIS |
摘要 |
Materials and Methods related to Dickkopfs and Neurogenesis Abstract Methods for promoting dopaminergic neuronal development and producing neural cells having a dopaminergic phenotype. Dopaminergic neural cells may be used for treating individuals having a neurodegenerative disease such as Parkinson's disease. Dopaminergic cells may be implanted into the brain of the individual, and/or dopaminergic neural development may be induced or enhanced in the brain of the individual. Methods comprise treating the cell with a Dkk ligand, such as any one of Dkk1 to Dkk4 or a fragment thereof comprising a cysteine rich domain, or a Dkk receptor such as LRP5 or LRP6, thereby producing or enhancing proliferation, self-renewal, survival and/or dopaminergic induction, differentiation, survival or acquisition of a neuronal dopaminergic phenotype. The cell may be co-cultured with astrocytes or glial cells and may be contacted with an FGF growth factor. Dopaminergic neurons may also be useful in drug/toxicology testing and for target development or drug discovery. |
申请公布号 |
WO2006061717(A3) |
申请公布日期 |
2007.07.05 |
申请号 |
WO2005IB03996 |
申请日期 |
2005.12.09 |
申请人 |
NEURO THERAPEUTICS AB;ARENAS, ERNESTO;CASTELO BRANCO, GONCALO;SOUSA, KYLE |
发明人 |
ARENAS, ERNESTO;CASTELO BRANCO, GONCALO;SOUSA, KYLE |
分类号 |
A61K38/00;C12N5/079;C12N5/0793 |
主分类号 |
A61K38/00 |
代理机构 |
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