C3-CONVERTASE INHIBITORS FOR THE PREVENTION AND TREATMENT OFAGE-RELATED MACULAR DEGENERATION IN PATIENTS WITH AT RISK VARIANTS OF COMPLEMENT FACTOR H

摘要

The present invention provides methods for identifying a patient at risk for developing AMD by identifying the presence of the Y402H polymorphism or other at risk variants in the complement factor H gene. The present invention further provides methods for treating persons having AMD or at risk for developing AMD as a result of having the Y402H polymorphism or other at risk variants in the complement factor H gene.