发明名称 |
Methods and compositions for the treatment and diagnosis of diseases characterized by vascular leak, hypotension, or a procoagulant state |
摘要 |
Disclosed herein are methods for treating a vascular leak disorder, hypotension, or a procoagulant state using angiopoietin-2 (Ang-2) antagonist compounds. Also disclosed are methods for treating a vascular leak disorder associated with high dose IL-2 therapy using angiopoietin-2 antagonist compounds. Methods for diagnosing and monitoring vascular leak disorders, hypotension, or a procoagulant state that include the measurement of Ang-2 polypeptide or nucleic acid levels are also disclosed. Methods for inducing a vascular leak using an Ang-2 agonist are also disclosed.
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申请公布号 |
US2007154482(A1) |
申请公布日期 |
2007.07.05 |
申请号 |
US20060519954 |
申请日期 |
2006.09.12 |
申请人 |
BETH ISRAEL DEACONESS MEDICAL CENTER |
发明人 |
SUKHATME VIKAS P.;KARUMANCHI S. A.;PARIKH SAMIR M. |
分类号 |
A61K39/395;A61K31/43;A61K31/545;A61K31/573;G01N33/53 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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