IMPROVED MONOCYTE ACTIVATION TEST BETTER ABLE TO DETECT NON-ENDOTOXIN PYROGENIC CONTAMINANTS IN MEDICAL PRODUCTS

摘要

An improved monocyte activation test is described that is better able to
detect non-endotoxin pyrogens in medical
products, in which a sample is incubated with a monocyte-containing reagent in
an assay system comprising at least one surface
comprising polypropylene. The invention also concerns assay systems for use in
these tests that include at least one microtiter
well having at least one interior surface comprising polypropylene and having
a shape such that monocyte-containing reagent is
concentrated in the well to provide greater cell to cell contact. The
invention also relates to a diagnostic kit that can be used to test
for the presence of non-endotoxin pyrogens in a sample.