CLOSED-LOOP STATE-DEPENDENT SEIZURE PREVENTION SYSTEMS

摘要

The invention provides novel closed-loop neuroprosthetic devices and systems for preventing seizures in which control of the delivery of therapeutic electrical stimulation to a neural structure being monitored is determined by the dynamical electrophysiological state of the neural structure. In certain embodiments, a controller which generates predetermined control input is activated based on an Automated Seizure Warning system. Other embodiments of the systems and methods encompass direct control systems wherein the controller design is based on chaos theory. Yet other versions embody model-based control systems in which controller design is based on a model that represents the relationship between the control input and the dynamical descriptor.