发明名称 |
RECEPTOR-BINDING CYCLIC PEPTIDES AND METHODS OF USE |
摘要 |
The present invention provides novel receptor-binding cyclic peptides that advantageously display high receptor binding affinity and selectively. More particularly, the present invention provides integrin-binding cyclic peptides containing an integrin-binding motif such as an RGD motif, an aromatic amino acid such as a tyrosine residue, and a lysine residue having a pi-pi stacking moiety conjugated to its -amino group. Methods for identifying receptor-binding cyclic peptides and for using the cyclic peptides of the present invention for imaging a tumor, organ, or tissue and for treating cancer, inflammatory diseases, and autoimmune diseases are also provided.
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申请公布号 |
WO2006017619(A3) |
申请公布日期 |
2007.07.05 |
申请号 |
WO2005US27654 |
申请日期 |
2005.08.05 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;SUTCLIFFE-GOULDEN, JULIE;MARSHALL, JOHN;HOWARD, MARK;O'DOHERTY, MICHAEL |
发明人 |
SUTCLIFFE-GOULDEN, JULIE;MARSHALL, JOHN;HOWARD, MARK;O'DOHERTY, MICHAEL |
分类号 |
A61K38/00 |
主分类号 |
A61K38/00 |
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