ENHANCING TREATMENT OF HIF-1 MEDIATED DISORDERS WITH ADENOSINE A3 RECEPTOR AGONISTS

摘要

The present invention relates to the use of adenosine receptor agonists, preferably A3 receptor agonists, either alone or in combination with other agents for the treatment, prevention and/or management of diseases or disorders associated with under­expression of HIF-1 a and/or decreased HIF-1 a<I/>activity (e.g., ischemic related disorders). The methods of the invention are directed to methods of reducing tissue damage (e.g., substantially preventing tissue damage, inducing tissue protection) resulting from ischemia orhypoxia. The invention provides methods for treating, preventing and/or ameliorating one or more symptoms of hypoxic or HIF-la related disorders by administering an A3 receptor agonist either alone or in combination with other agents.