摘要 |
<p>Propiolic acid amides (I), optionally as pure stereoisomers, particularly enantiomers or diastereomers, including racemates and mixtures in any proportion, also salts and solvates, are new. Propiolic acid amides of formula A-N(R 1>)-(CR 2>R 3>) a-(CR 4>R 5>) b-(CR 6>R 7>) c-NR 8>-CO-Ctriple boundC-R 9> (I), optionally as pure stereoisomers, particularly enantiomers or diastereomers, including racemates and mixtures in any proportion, also salts and solvates, are new a, b and c : 0 or 1, totaling 1-3; A : particular heterocyclic groups; R 1>-R 8>hydrogen or various substituents Full definitions are given in the DEFINITIONS -Full Definitions field. An independent claim is included for several methods for preparing (I). ACTIVITY : Analgesic; Antimigraine; Antidepressant; Nootropic; Neuroprotective; Antiparkinsonian; Anticonvulsant; Tranquilizer; Antitussive; Uropathic; Antidiarrheal; Antipruritic; Antiasthma; Cerebroprotective; Ophthalmological; Antialcoholic; Antismoking. MECHANISM OF ACTION : Regulation, particularly inhibition, of the mGluR5 receptor. The compound 1-(3-phenylpropiolyl)-4-(thiophen-3-yl)-piperazine has IC50 against the porcine mGluR5 receptor of 1.89 mu M.</p> |