发明名称 |
EIN VERFAHREN ZUR HERSTELLUNG VON 1-ALPHA-HYDROXY-2-METHYLEN-19-NOR-HOMOPREGNACALCIFEROL |
摘要 |
<p>A method of making 1alpha-hydroxy-2-methylene-19-nor-homopregnacalciferol. The method includes the steps of condensing a bicyclic ketone with an allylic phosphine oxide to produce a protected 19-nor-pregnacalciferol analog, thereafter cleaving the protecting group to form 22-alcohol, converting the alcohol to an ester, reducing the ester to 17beta-isopropyl-19-nor-vitamin D analog, and finally deprotecting the 17beta-isopropyl derivative to form the desired compound.</p> |
申请公布号 |
DE60310050(T2) |
申请公布日期 |
2007.07.05 |
申请号 |
DE2003610050T |
申请日期 |
2003.03.26 |
申请人 |
WISCONSIN ALUMNI RESEARCH FOUNDATION |
发明人 |
DELUCA, F.;GOWLUGARI, SUMITHRA;SICINSKI, R. |
分类号 |
C07C401/00 |
主分类号 |
C07C401/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|