| 摘要 |
PROBLEM TO BE SOLVED: To produce an optically active 3-(3-hydroxyphenyl)-2-alkoxypropanoic acid (2), etc., by asymmetric hydrolysis with an enzyme. SOLUTION: This method for producing a compound (2), etc., is provided by performing the asymmetric hydrolysis by using the following asymmetric hydrolase having a capacity of hydrolyzing the ester group of one of its mirror image isomer preferentially in a mixture of the mirror image isomers of a 3-(3-hydroxyphenyl)-2-alkoxypropanoic acid ester (1) [wherein, R<SP>1</SP>is a 1-4C alkyl; R<SP>2</SP>is a 1-6C alkyl; and a carbon atom attached with * mark is an asymmetric carbon], or a cultured material or its treated material of microorganisms having a production capacity of the enzyme. [Asymmetric hydrolase] The hydrolases originated from the microorganisms selected from a group consisting of the genus Penicillium, Pseudomonas, Rhizomucor and Arthrobacter can be used. COPYRIGHT: (C)2007,JPO&INPIT
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