NANOPARTICLE CONTAINING WATER-SOLUBLE NON-PEPTIDIC LOW MOLECULAR WEIGHT SUBSTANCE

摘要

Disclosed is a nanoparticle containing a water-soluble non-peptidic low molecular weight substance, which is excellent in targeting of the substance to an affected part and sustained release of the substance and shows a reduced accumulation of the substance in the liver. The nanoparticle can be prepared by hydrophobizing a water-soluble non-peptidic low molecular weight substance with a metal ion and then reacting the hydrophobized substance with a polylactic acid-polyethylene glycol block copolymer or a poly(lactic acid/glycolic acid)-polyethylene glycol block copolymer.