| 摘要 |
A simple, efficient apparatus and method for separation of solid and liquid phases useful in methods of high-throughput combinatorial organic synthesis of large libraries or megaarrays of organic compounds is disclosed. The method for separating a liquid phase from a solid phase during a solid phase organic synthetic process comprises: (1) positioning a reaction vessel or one or more arrays of reaction vessels, such as one or more microtiter plates, said vessels containing a slurry of solid phase particles or beads in a liquid, on the perimeter of a centrifuge rotor in a tilted or not tilted position; and (2) spinning the rotor of the centrifuge at a speed so that the solid phase particles sediment in a"pocket" of the vessels and the liquid phase is expelled from the vessels. The apparatus and method are useful, whether as part of an automated, robotic or manual system for combinatorial organic synthesis. In a preferred embodiment, an apparatus and method of removal of liquid phase from solid phase compatible with microtiter plate type array(s) of reaction vessels is disclosed. |
