发明名称 |
SUBSTITUTED TRIAZOLO-PYRIDAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS |
摘要 |
A class of substituted or 7,8-ring fused 1,2,4triazolo[4,3-b]pyridazine derivatives, possessing an optionally substituted cycloalkyl, phenyl or heteroaryl substituent at the 3-position and a substituted alkoxy moiety at the 6-position, are selective ligands for GABA A receptors, in particular having high affinity for the a2 and/or 0 subunit thereof, and are accordingly of benefit in the treatment and/or prevention of disorders of the central nervous system, including anxiety and convulsions.
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申请公布号 |
CA2260774(C) |
申请公布日期 |
2007.07.03 |
申请号 |
CA19972260774 |
申请日期 |
1997.07.17 |
申请人 |
MERCK SHARP & DOHME LIMITED |
发明人 |
RUSSELL, MICHAEL GEOFFREY;GUIBLIN, ALEXANDER RICHARD;CASTRO PINEIRO, JOSE LUIS;MOORE, KEVIN WILLIAM;CARLING, WILLIAM ROBERT;STREET, LESLIE JOSEPH;BROUGHTON, HOWARD BARFF;MADIN, ANDREW |
分类号 |
C07D487/04;A61K31/50;A61K31/5025;A61K31/505;A61K31/535;A61K31/54;A61K47/48;A61P25/00;A61P25/08;A61P25/22;A61P43/00;C07D;C07D471/14;C07D487/08;G01N33/566 |
主分类号 |
C07D487/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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