Compositions and methods for treating amyloidosis using sulphonate derivatives

摘要

Disclosed is the use of compounds of the formula I in compositions for inhibiting, preventing and treating amyloid aggregation, e.g. in pancreatic islets wherein the amyloidotic aggregates to be treated are in an embodiment, islet amyloid polypeptide (IAPP)-associated amyloid aggregates, e.g. having at least some beta-sheet structure. Accordingly, the compositions and compounds are useful for inhibiting amyloidosis in disorders in which such amyloid aggregation occurs e.g. Alzheimer's disease.