This disclosure provides methods and compositions for treating disorders or injuries that affect motor function and control in a subject. In one aspect, the invention provides a method to deliver a transgene to a subject's spinal cord by administering a recombinant neurotropic viral vector containing the transgene. The viral vector delivers the transgene to a region of the deep cerebellar nuclei region of the brain. Also provided are compositions and methods to deliver a transgene to a subject's spinal cord by administering a recombinant neurotropic viral vector containing the transgene to the motor cortex region of the subject's brain.
申请公布号
WO2006119341(A3)
申请公布日期
2007.06.28
申请号
WO2006US16943
申请日期
2006.05.02
申请人
GENZYME CORPORATION;DODGE, JAMES;SHIHABUDDIN, LAMYA;PASSINI, MARCO;CHENG, SENG
发明人
DODGE, JAMES;SHIHABUDDIN, LAMYA;PASSINI, MARCO;CHENG, SENG