发明名称 |
METHOD FOR TREATING MALIGNANT MELANOMA |
摘要 |
<p>The present invention discloses an immunotherapeutic method for treating patients suffering from malignant melanoma, by administering expanded tumour-reactive CD4+ helper and/or CD8+ T-lymphocytes obtainable from one or more sentinel or metinel lymph nodes draining a malignant melanoma or a metastasis arising from malignant melanoma. The present invention provides a new effective method for treating malignant melanoma and metastatic malignant melanoma, without adverse side effects associated with the known treatments. The method comprises identification of in a patient one or more sentinel and/or metinel lymph nodes draining a malignant melanoma or a metastasis there from, resection of the one or more nodes and, optionally all or part of the tumour or metastasis, isolation of tumour-reactive T- lymphocytes from said lymph nodes, in vitro expansion of said tumour-reactive T- lymphocytes, and administration of the thus obtained tumour-reactive T-lymphocytes to the patient, wherein the T-lymphocytes are CD4+ helper and/or CD8+ T-lymphocytes.</p> |
申请公布号 |
WO2007071390(A1) |
申请公布日期 |
2007.06.28 |
申请号 |
WO2006EP12306 |
申请日期 |
2006.12.20 |
申请人 |
SENTOCLONE THERAPEUTICS AB;WINQVIST, OLA;THOERN, MAGNUS |
发明人 |
WINQVIST, OLA;THOERN, MAGNUS |
分类号 |
A61K35/14;A61K35/26;A61K38/20;A61K38/21;A61K39/00;C12N5/0783;G01N33/50 |
主分类号 |
A61K35/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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