摘要 |
Provided herein are methods and compositions for treating or preventing neurodegenerative disorders or blood coagulation disorders. Methods may comprise modulating the activity or level of a sirtuin, such as SIRTl or Sir2. Exemplary methods comprise contacting a cell with a sirtuin activating compound, such as a flavone, stilbene, flavanone, isoflavone, catechin, chalcone, tannin or anthocyanidin; or an inhibitory compound, such as nicotinamide. |
申请人 |
SIRTRIS PHARMACEUTICALS, INC.;MILBURN, MICHAEL;MILNE, JILL;WESTPHAL, CHRISTOPHER, H.;NORMINGTON, KARL, D.;FUJII, JENNIFER;DIPP, MICHELLE;ELLIOT, PETER |
发明人 |
MILBURN, MICHAEL;MILNE, JILL;WESTPHAL, CHRISTOPHER, H.;NORMINGTON, KARL, D.;FUJII, JENNIFER;DIPP, MICHELLE;ELLIOT, PETER |