METHODS FOR TESTING VACCINE CANDIDATES AGAINST BACTERIAL INFECTION IN RODENTS

摘要

Methods and a rodent model to test the effectiveness of vaccine candidates against bacteria, e.g., Staphylococcus aureus by systemically immunizing a rodent, particularly a cotton rat, with a vaccine candidate, intranasally challenging the cotton rat with the selected bacteria, and detecting a response with respect to an immune response, nasal colonization as a measure of the protective effect of the vaccine candidate, or both.