发明名称 |
KIT AND COMPOSITION OF IMIDAZOLE WITH ENHANCED BIOAVAILABILITY |
摘要 |
A composition and therapeutic kit provide a therapeutic azole with increased solubility. The kit includes an aerosol packaging assembly containing a container accommodating a pressurized product and an outlet capable of releasing the pressurized product as a foam. The pressurized product includes a foamable composition including: i. a therapeutic azole, wherein the solubility of the azole in the composition before foaming is less than the solubility of the azole in the composition after foaming; ii. at least one organic carrier selected from the group consisting of a hydrophobic organic carrier, a co-solvent, an emollient and mixtures thereof, at a concentration of about 2% to about 50% by weight; iii. a surface-active agent; iv. about 0.01% to about 5% by weight of at least one polymeric additive selected from the group consisting of a bioadhesive agent, a gelling agent, a film forming agent and a phase change agent; v. water; and vi. liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition. |
申请公布号 |
WO2007072216(A2) |
申请公布日期 |
2007.06.28 |
申请号 |
WO2006IB03974 |
申请日期 |
2006.01.24 |
申请人 |
FOAMIX LTD.;TAMARKIN, DOV;FRIEDMAN, DORON;EINI, MEIR |
发明人 |
TAMARKIN, DOV;FRIEDMAN, DORON;EINI, MEIR |
分类号 |
A61K9/00;A61L9/04;A61M11/00 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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