PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH

摘要

The present invention relates to a compound of the formula (I), or a pharmaceutically acceptable salt thereof, wherein Ar is a group of formula (III), and R¹, R², R¹³, A, K, M, L¹, L², X, Y¹, Y², Q, salt thereof, wherein R¹, R², R¹³, A, K, L¹, L², W, X, Z¹, Z², Y¹, Y², Z¹, Z², M, Q, W, X, m, p and q are as defined herein. Such novel pyrimidine derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.