| 摘要 |
A method is disclosed for treating hyperproliferative body surface lesions, including cancerous or precancerous lesion, such as warts or anogenital cancers, by applying a polyaryl mononitro- or dinitrophenylhydrazone such as (I) wherein R<SUP>1</SUP> is hydrogen, hydroxy, 2- or 4-hydroxyphenyl, acetate, nitroso, phosphate, azido, nitrile, amino, dimethylamino, sulfate, methylsulfonate, phosphate, succinate or another water soluble electrophilic group capable of hydrogen bonding; R<SUP>2</SUP> is C<SUB>6</SUB>H<SUB>4</SUB>OH, C<SUB>6</SUB>H<SUB>4</SUB>N<SUB>3</SUB>, C<SUB>6</SUB>H<SUB>4</SUB>CN, 4-HO-C<SUB>6</SUB>H<SUB>4</SUB>-C<SUB>6</SUB>H<SUB>4</SUB>, C<SUB>6</SUB>H<SUB>4</SUB>OPO<SUB>2</SUB>OH, C<SUB>6</SUB>H<SUB>4</SUB>OSO<SUB>2</SUB>H, C<SUB>6</SUB>H<SUB>4</SUB>NH<SUB>2</SUB>, C<SUB>6</SUB>H<SUB>4</SUB>NHM<SUB>e2</SUB>, C<SUB>6</SUB>H<SUB>4</SUB>OSO<SUB>2</SUB>Me, C<SUB>6</SUB>H<SUB>4</SUB>OCO(CH<SUB>2</SUB>)<SUB>x</SUB>CO<SUB>2</SUB>H, or C<SUB>6</SUB>H<SUB>5</SUB>Cl; and X is C<SUB>6</SUB>H<SUB>3</SUB>-2,4(NO<SUB>2</SUB>)<SUB>2</SUB>, C<SUB>6</SUB>H<SUB>4</SUB>-4(NO<SUB>2</SUB>), C<SUB>6</SUB>H<SUB>4</SUB>-3 (NO<SUB>2</SUB>), or C<SUB>6</SUB>H<SUB>3</SUB>-2,4(NO<SUB>2</SUB>)<SUB>2</SUB>. In a particular example, R<SUP>1</SUP> is OH, R<SUP>2</SUP> is C<SUB>6</SUB>H<SUB>4</SUB>OH and X is C<SUB>6</SUB>H<SUB>3</SUB>-2,4(NO<SUB>2</SUB>)<SUB>2</SUB>. |
