Development of biomarker for prognosis of therapeutic treatment on basis of data from clinical studies, comprises determining maximum markers from parameter and complexity, and determining defined parameter by sequential combination

摘要

Procedure for the development of biomarker for the prognosis of a therapeutic treatment on the basis of data from clinical studies, where the unchanged data of the therapy are divided into diagnostic and genomic parameters, and the marker is defined by a combination of parameter, comprises determining the maximum number markers from the parameter and maximum complexity of the system; and determining the defined parameter takes place by sequential combination of clinical parameter (=z-parameter) and/or genomic parameter (=x-parameter).