摘要 |
<p>The present invention concerns aryl and heteroaryl substituted pyrazinone derivatives having antagonistic melanin-concentrating hormone (MCH) activity, in particular MCH-I activity according to the general Formula (I) a pharmaceutically acceptable acid or base addition salt thereof, a stereo chemically isomeric form thereof, an TV-oxide form thereof or a quaternary ammonium salt thereof, wherein the variables are defined in Claim 1. It further relates to their preparation, compositions comprising them and their use as a medicine. The compounds according to the invention are usefull for the prevention and/or treatment of psychiatric disorders, including but not limited to anxiety, eating disorders, mood disorders, such as bipolar disorders and depression, psychoses, such as schizophrenia, and sleeping disorders ; obesity ; diabetes ; sexual disorders and neurological disorders.</p> |
申请人 |
JANSSEN PHARMACEUTICA N.V.;ANDRES-GIL, JOSE, IGNACIO;ALCAZAR-VACA, MANUEL, JESUS;ALVAREZ-ESCOBAR, ROSA, MARIA;OYARZABAL SANTAMARINA, JULEN;DAUTZENBERG, FRANK, MATTHIAS;MACRITCHIE, JACQUELINE;SIMPSON, DONALD;MARTINEZ GONZALEZ, SONIA |
发明人 |
ANDRES-GIL, JOSE, IGNACIO;ALCAZAR-VACA, MANUEL, JESUS;ALVAREZ-ESCOBAR, ROSA, MARIA;OYARZABAL SANTAMARINA, JULEN;DAUTZENBERG, FRANK, MATTHIAS;MACRITCHIE, JACQUELINE;SIMPSON, DONALD;MARTINEZ GONZALEZ, SONIA |