发明名称 |
Process for detecting predisposition to a cardiovascular disease |
摘要 |
Includes the identification in the genetic material of an isolated biological sample from said human an allelic variant which consist on the substitution of a cytosine by an tymine in the position 46 over the transcriptional origin of Factor XII (46C/T) within the locus of chromosome 5, limited by the D5S400 and D5S408 markers, being the presence of said allelic variant is indicative of a predisposition to a cardiovascular disease. In said process, use is made of a biological sample susceptible of including at least one allelic variant within the chromosome 5 locus limited by the D5S400 and D5S408 markers in order to determine a predisposition to cardiovascular diseases which manifest with thrombotic events. The process permits detection of a predisposition to a cardiovascular disease in a human, so that a suitable preventive an therapeutic strategy can be designed. |
申请公布号 |
AU2003201505(B2) |
申请公布日期 |
2007.06.28 |
申请号 |
AU20030201505 |
申请日期 |
2003.01.30 |
申请人 |
FUNDACIO PRIVADA I INSTITUT DE RECERCA DE L'HOSPITAL DE LA SANTA CREU I SANT PAU |
发明人 |
JORDI FONTCUBERTA BOJ;JOSE MANUEL SORIA FERNANDEZ |
分类号 |
G01N33/50;C12N15/09;C12Q1/37;C12Q1/68;G01N33/48 |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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