Medicinal composition as immunosuppressant

摘要

A pharmaceutical composition useful as a preventive or therapeutic agent for immune-related diseases. The pharmaceutical composition includes at least HMG-COA reductase inhibitor and at least one amino alcohol compound having the following formula (I), a pharmacologically acceptable salt thereof, or a pharmacologically acceptable ester thereof wherein R¹ and R² each represents hydrogen; R³ represents lower alkyl or hydroxymethyl; R⁴ represents hydrogen, alkyl, alkoxy or halogen; R⁵ represents hydrogen, halogeno, cyclohexyl or phenyl; X represents vinylene (CH-CH), oxygen, sulfur or methylated nitrogen; Y represents a single bond, oxygen, sulfur or carbonyl; Z represents a single bond or C₁-C₈ alkylene; n is 2 or 3.