发明名称 |
Pituitary adenylate cyclase-activating polypeptide (PACAP) is an anti-mitogenic signal for selected neuronal precursors in vivo |
摘要 |
Pituitary adenylate cyclase-activating polypeptide (PACAP) and its receptor system can be manipulated positively or negatively to regulate mitosis in neuronal precursor cells. The ligand/receptor system involves PACAP, PACAP receptor, PAC<SUB>1</SUB>, and related antagonists. The methods of regulation of the present invention may model be used to define cell cycle regulation in the developing neurons. The present invention may also be used to control or cure diseases related to or caused by damage to or destruction of neuronal cells.
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申请公布号 |
US2007149439(A1) |
申请公布日期 |
2007.06.28 |
申请号 |
US20050240737 |
申请日期 |
2005.09.30 |
申请人 |
DICICCO-BLOOM EMANUEL;NICOT ARNAUD;LU NAIRU;SUH JUNGHYUP |
发明人 |
DICICCO-BLOOM EMANUEL;NICOT ARNAUD;LU NAIRU;SUH JUNGHYUP |
分类号 |
A61K38/17;A61K38/22;C07K16/26;C12N5/0797 |
主分类号 |
A61K38/17 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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