Process for the manufacture of particles containing antibotics and their application

摘要

Producing antibiotic particles involves mixing an aqueous solution of an amino glycoside-antibiotic or an aqueous solution comprising at least two amino glycoside-antibiotics under agitation with a solvent mixture comprising isopropanol and at least one additional alcohol, with the volume ratio of the solvent mixture to the aqueous solution of at least 3:1 to obtain a suspension having coarse antibiotic aggregates; and agitating or leaving standing the suspension obtained until the coarse antibiotic aggregates disintegrate into particles having a grain size smaller than 400 mu m. An independent claim is included for a polymethyl methacrylate-bone cement comprising the antibiotic particles having grain size of 63 - 400 mu m. ACTIVITY : Antibacterial. No biological data given. MECHANISM OF ACTION : None given.