发明名称 |
Method for preparing submicron particle suspensions |
摘要 |
<p>The present invention provides a method a method for preparing a suspension of a pharmaceutically-active compound, the solubility of which is greater in a water-miscible first organic solvent than in a second solvent which is aqueous, the process comprising the steps of (i) dissolving a first quantity of the pharmaceutically-active compound in the water-miscible first organic solvent to form a first solution; (ii) mixing the first solution with the second solvent to precipitate the pharmaceutically-active compound to create a presuspension; and (iii) seeding the first solution or the second solvent prior to the mixing step or seeding the pre-suspension after the mixing step.</p> |
申请公布号 |
EP1642571(A3) |
申请公布日期 |
2007.06.27 |
申请号 |
EP20050077486 |
申请日期 |
2001.12.20 |
申请人 |
BAXTER INTERNATIONAL INC. |
发明人 |
KIPP, JAMES E.;WONG, JOSEPH CHUNG TAK;DOTY, MARK J.;REBBECK, CHRISTINE L.;BRYNJELSEN, SEAN;WERLING, JANE;SRIRAM, RAJARAM |
分类号 |
C07D407/14;A61K9/10;A61K9/14;A61K9/16;A61K31/495;A61K31/496;A61K47/12;A61K47/14;A61K47/18;A61K47/20;A61K47/24;A61K47/28;A61K47/34;A61K47/36;A61K47/38;A61K47/42;A61P31/10;B01D9/02;B01D21/01 |
主分类号 |
C07D407/14 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|