| 摘要 |
An oral formulation which includes an intragranular phase comprising a bisphosphonic acid derivative and at least one carbohydrate alcohol, together with an aqueous binder. A process of preparing the same and a therapeutic method employing such a formulation in the treatment of various skeletal diseases, such as systemic bone diseases including osteoporosis, osteoarthritis, Paget's disease, osteomalacia, multiple myeloma, and other forms of cancer, steroid therapy wherein the skeletal system is effected and age-related loss of bone mass, local disorders such as bone fractures and other such related disorders. |
