发明名称 |
UTILIZATION OF SPERM MEMBRANE PROTEIN OBF |
摘要 |
<p>The present invention yielded unique monoclonal antibodies that reacted specifically only to sperms after acrosome reaction, and the antigens (OBFs) recognized by the antibodies were identified. The antibodies were found to inhibit fusion between mouse sperms and eggs. Furthermore, OBF gene-knockout mice were created and analyzed to clarify the <Italic>in vivo</Italic> functions of OBF. As a result, male OBF gene-knockout mice were shown to be infertile, and their sperms were shown to be able to bind to eggs, but had no fusion ability.</p> |
申请公布号 |
EP1801124(A1) |
申请公布日期 |
2007.06.27 |
申请号 |
EP20050781302 |
申请日期 |
2005.08.31 |
申请人 |
CHUGAI SEIYAKU KABUSHIKI KAISHA |
发明人 |
OKABE, MASARU;INOUE, NAOKAZU |
分类号 |
C07K16/18;A01K67/027;A61K38/00;A61K39/35;A61K39/395;A61P15/16;C07K14/47;C12N5/10;C12N15/09;C12Q1/02;C12Q1/68;G01N33/15 |
主分类号 |
C07K16/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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