发明名称 |
PURINE AND PYRIMIDINE CDK INHIBITORS AND THEIR USE FOR THE TREATMENT OF AUTOIMMUNE DISEASES |
摘要 |
<p>The present invention relates to the use of an inhibitor of CDK2 and/or CDK7 and/or CDK9, or a pharmaceutically acceptable salt thereof, in the preparation of a medicament for treating a disease associated with antinuclear antibodies, wherein the inhibitor of CDK2 and/or CDK7 and/or CDK9 or pharmaceutically acceptable salt thereof is administered in an amount sufficient to down-regulate the levels of antinuclear antibodies. A further aspect of the invention relates to a combination comprising an inhibitor of CDK2 and/or CDK7 and/or CDK9, or a pharmaceutically acceptable salt thereof, and methylprednisolone, and its use in the treatment of diseases associated with antinuclear antibodies, such as SLE.</p> |
申请公布号 |
EP1799230(A2) |
申请公布日期 |
2007.06.27 |
申请号 |
EP20050775408 |
申请日期 |
2005.08.25 |
申请人 |
CYCLACEL LIMITED |
发明人 |
BENIGNI, ARIELA;ZOJA, CARLA;REMUZZI, GIUSEPPE;GIANNELLA-BORRADORI, ATHOS |
分类号 |
A61K31/7076;A61K31/7064;A61P19/02;A61P37/06;A61P43/00 |
主分类号 |
A61K31/7076 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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