| 发明名称 |
DERIVATIVES OF THIAZOLE POSSESSING ANTAGONISTIC, AGONISTIC OR PARTIALLY AGONISTIC CB1-ACTIVITY |
| 摘要 |
FIELD: organic chemistry, medicine, biology. ^ SUBSTANCE: invention relates to novel derivatives of thiazole that are strong antagonists, agonists or partial agonists of cannabinoid CB1 receptors. Compounds show the general formula (I): wherein R and R1-R4 have values given in the invention claim. Also, invention relates to using compounds of the formula (I) or their stereoisomers for preparing a pharmaceutical composition. Also, invention relates to intermediate compounds of the formula (V): wherein R2 and R8 have values given in the invention claim. ^ EFFECT: valuable medicinal and biological properties of compounds. ^ 5 cl, 1 tbl, 7 ex |
| 申请公布号 |
RU2301804(C2) |
申请公布日期 |
2007.06.27 |
| 申请号 |
RU20040114263 |
申请日期 |
2003.03.17 |
| 申请人 |
SOLVEJ FARMAS'JUTIKALS B.V. |
发明人 |
LANGE JOSEFUS KH.M.;KRJUSSE KORNELIS G.;KHERREMANS ARNOL'DUS KH.J.;VAN STEJVENBERG KHERMAN KH.;DEJKSMAN DZHESSIKA A.R.;MAKRIRI EHNDRJU K. |
| 分类号 |
C07D277/20;C07D277/56;A61K31/425;A61K31/426;A61K31/427;A61K31/454;A61K31/5377;A61K31/55;A61P1/00;A61P1/04;A61P1/08;A61P1/12;A61P1/14;A61P3/04;A61P3/10;A61P7/00;A61P9/00;A61P9/10;A61P11/00;A61P11/06;A61P25/00;A61P25/02;A61P25/04;A61P25/08;A61P25/14;A61P25/16;A61P25/18;A61P25/22;A61P25/24;A61P25/28;A61P25/30;A61P25/36;A61P27/06;A61P31/04;A61P31/12;A61P35/00;A61P41/00;A61P43/00;C07D277/00;C07D277/68;C07D417/00;C07D417/12 |
主分类号 |
C07D277/20 |
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