BI- AND TRICYCLIC SUBSTITUTED PHENYL METHANONES AS GLYCINE TRANSPORTER I (GLYT-1) INHIBITORS FOR THE TREATMENT OF ALZHEIMER S DISEASE.

摘要

The present invention relates to compounds of the general formula (I), wherein formula (II) is A or B or C or D or E or F. R1 is a non aromatic heterocycle, or is OR' or N(R")2; R' is lower alkyl, lower alkyl substituted by halogen or is -(CH2)ri cycloalkyl; R" is lower alkyl; R2 is NO2, CN or SO2R"; R3 is hydrogen, halogen, lower alkyl, lower alkoxy, or lower alkyl substituted by halogen; R4 is hydrogen, lower alkyl, phenyl substituted by halogen or CF3, or is a five or six membered aromatic heterocycle; R5/R6 are hydrogen, halogen, lower alkyl, lower alkoxy, or are lower alkyl or lower alkoxy, substituted by halogen; R7 is hydrogen or lower alkyl; n is 0, 1 or 2; and to pharmaceutically active acid addition salts for the treatment of neurological and neuropsychiatric disorders.