| 摘要 |
A chromatographic separation process of a type wherein a feedstock fluid containing a plurality of components is supplied into a circulative chromatographic separation system, the process comprising the steps of (i) supplying the feedstock fluid and withdrawing a fraction enriched in a component, (ii) supplying a desorbent fluid and withdrawing a fraction enriched in another component, and (iii) circulating the fluid through the bed without supplying or withdrawing any fluid thereby making a mixed zone comprising a plurality of components move, a cycle including steps (i), (ii) and (iii) being repeated, wherein the packed bed comprises a first unit bed packed with an adsorbent, to which she feedstock fluid is supplied, and at least one other unit bed packed with an adsorbent, and the adsorbent (e.g., ion-exchange resin) packed into the first unit bed, to which the feedstock fluid is supplied, has a greater average particle size and/or a higher degree of crosslinking than that packed in the at least one other unit packed bed. -45-
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