CHLORINATION OF HETEROCYCLIC COMPOUNDS USING PHOSPHORUS OXYCHLORIDE AND BENZYLTRIETHYLAMMONIUM CHLORIDE

摘要

A method for chlorinating a nitrogen containing-heterocyclic compound is provided to obtain a chloride with high yield and high purity through a simplified post-treating step and a purification step by using POCl3 and benzyltriethylammonium chloride. In the chlorinating method of substituting an oxygen atom in a carbonyl group existent in an alpha-position of a nitrogen-containing heterocyclic compound with a chlorine atom, the chlorination is performed using 2-25 equivalents of POCl3 as a chlorinating agent and 1-3 equivalents of benzyltriethylammonium chloride as an acid binder. The product obtained by the chlorination is further purified by washing it with water or recrystallizing it using hexane.