| 摘要 |
<p>An anti-glypican 3 antibody having a modified sugar chain, more specifically, an anti-glypican 3 antibody lacking fucose. This anti-glypican 3 antibody can be produced by a method for producing an antibody with the sugar chain modification as described above wherein a nucleic acid encoding an anti-glypican 3 antibody is transferred into host cells with lowered ability to add fucose (for example, YB2/0cells) or fucose transporter-deficient cells and then the host cells are cultured. Because of having a high cytotoxic activity, this anti-glypican 3 antibody having a modified sugar chain is useful as a cell growth inhibitor such as an anticancer agent.</p> |
